293407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2769887..2771130 Replicon chromosome
Accession NZ_LT632615
Organism Legionella pneumophila strain ST23 isolate ST23

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag BQ6063_RS12680 Protein ID WP_061690682.1
Coordinates 2770192..2771130 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag BQ6063_RS12675 Protein ID WP_027224429.1
Coordinates 2769887..2770195 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ6063_RS12625 2765056..2765241 - 186 Protein_2438 hypothetical protein -
BQ6063_RS12635 2765622..2766320 + 699 WP_011947266.1 hypothetical protein -
BQ6063_RS12640 2766410..2766529 + 120 Protein_2440 IS3 family transposase -
BQ6063_RS12645 2766526..2766832 - 307 Protein_2441 hypothetical protein -
BQ6063_RS12650 2766879..2767190 - 312 WP_015961549.1 cupin -
BQ6063_RS12655 2767206..2767463 - 258 WP_061690683.1 hypothetical protein -
BQ6063_RS12660 2767639..2768112 + 474 WP_027224431.1 hypothetical protein -
BQ6063_RS12665 2768302..2769219 + 918 WP_014844533.1 LysR family transcriptional regulator -
BQ6063_RS12670 2769663..2769890 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
BQ6063_RS12675 2769887..2770195 + 309 WP_027224429.1 HipA N-terminal domain-containing protein Antitoxin
BQ6063_RS12680 2770192..2771130 + 939 WP_061690682.1 HipA domain-containing protein Toxin
BQ6063_RS12685 2771293..2772003 - 711 WP_027225948.1 outer membrane beta-barrel protein -
BQ6063_RS12695 2772487..2772780 - 294 WP_027219386.1 SNARE domain-containing protein -
BQ6063_RS12700 2772808..2773707 - 900 WP_061690681.1 hypothetical protein -
BQ6063_RS12705 2773870..2775324 + 1455 WP_027225951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36095.66 Da        Isoelectric Point: 8.9515

>T293407 WP_061690682.1 NZ_LT632615:2770192-2771130 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKMIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
EKNNLTKSDFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT293407 WP_027224429.1 NZ_LT632615:2769887-2770195 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References