Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2092147..2092649 Replicon chromosome
Accession NZ_LT615377
Organism Escherichia coli isolate 106

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag BV315_RS11385 Protein ID WP_000767829.1
Coordinates 2092147..2092401 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BV315_RS11390 Protein ID WP_001259255.1
Coordinates 2092398..2092649 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV315_RS11360 2087162..2087389 - 228 WP_000234896.1 sulfurtransferase TusA -
BV315_RS11365 2087403..2088461 - 1059 WP_000492339.1 transport protein YeeE -
BV315_RS11370 2088640..2089998 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
BV315_RS25165 2089988..2090050 - 63 WP_010723108.1 membrane protein YoeI -
BV315_RS11375 2090265..2091194 - 930 WP_000803351.1 LysR family transcriptional regulator -
BV315_RS11380 2091240..2092064 - 825 WP_000754737.1 SDR family oxidoreductase -
BV315_RS11385 2092147..2092401 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BV315_RS11390 2092398..2092649 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BV315_RS11395 2092932..2092982 + 51 WP_001364200.1 his operon leader peptide -
BV315_RS11405 2093128..2094027 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
BV315_RS11410 2094033..2095337 + 1305 WP_000009594.1 histidinol dehydrogenase -
BV315_RS11415 2095334..2096404 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
BV315_RS11420 2096404..2097471 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293349 WP_000767829.1 NZ_LT615377:c2092401-2092147 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293349 WP_001259255.1 NZ_LT615377:c2092649-2092398 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References