Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 23793..24384 Replicon chromosome
Accession NZ_LT615228
Organism Polynucleobacter necessarius isolate PPGSP1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DXE33_RS00145 Protein ID WP_114638120.1
Coordinates 23793..24071 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DXE33_RS00150 Protein ID WP_114639663.1
Coordinates 24082..24384 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE33_RS00125 18891..19825 - 935 Protein_24 uroporphyrinogen-III C-methyltransferase -
DXE33_RS00130 19860..20462 - 603 WP_114638118.1 DUF934 domain-containing protein -
DXE33_RS00135 20459..22187 - 1729 Protein_26 nitrite/sulfite reductase -
DXE33_RS00140 22362..23651 + 1290 WP_114638119.1 serine hydrolase -
DXE33_RS00145 23793..24071 + 279 WP_114638120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXE33_RS00150 24082..24384 + 303 WP_114639663.1 HigA family addiction module antidote protein Antitoxin
DXE33_RS00155 24423..24794 - 372 WP_114638121.1 hypothetical protein -
DXE33_RS00160 24845..25057 - 213 WP_162785383.1 hypothetical protein -
DXE33_RS00165 25314..25904 + 591 WP_114638123.1 HdeD family acid-resistance protein -
DXE33_RS00170 25954..26211 + 258 WP_114638124.1 hypothetical protein -
DXE33_RS00175 26324..26551 + 228 WP_114638125.1 hypothetical protein -
DXE33_RS00180 26561..28417 + 1857 WP_114638126.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10738.42 Da        Isoelectric Point: 9.9804

>T293319 WP_114638120.1 NZ_LT615228:23793-24071 [Polynucleobacter necessarius]
MIHSFSCKDTEDLFNSKSSKKLKGIERVARRKLLQLHAVTVLIDLRIPPGNMLEALSGNRKDQHSIRINNQWRICFKWKE
DGAYSVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11540.55 Da        Isoelectric Point: 6.4701

>AT293319 WP_114639663.1 NZ_LT615228:24082-24384 [Polynucleobacter necessarius]
MTKLLDEIHPGEILLEDFMKPMGITARQLAADIDVSPSRISEIVHGLRPITADTALRLGLFFSMEPRFWLNLQSEYDMRM
AKRTLQKEIEPRIRVFQIAA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References