Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 3537151..3537844 | Replicon | chromosome |
Accession | NZ_LT601384 | ||
Organism | Escherichia coli isolate NCTC86EC |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | S1EZG2 |
Locus tag | NCTC86EC_RS17400 | Protein ID | WP_000415584.1 |
Coordinates | 3537548..3537844 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | NCTC86EC_RS17395 | Protein ID | WP_000650107.1 |
Coordinates | 3537151..3537546 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NCTC86EC_RS17385 | 3533015..3535273 | - | 2259 | WP_001281881.1 | DNA topoisomerase IV subunit A | - |
NCTC86EC_RS17390 | 3535411..3537018 | - | 1608 | WP_021561146.1 | ABC transporter substrate-binding protein | - |
NCTC86EC_RS17395 | 3537151..3537546 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
NCTC86EC_RS17400 | 3537548..3537844 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
NCTC86EC_RS17405 | 3538049..3538531 | - | 483 | WP_000183505.1 | transcriptional regulator | - |
NCTC86EC_RS17410 | 3538584..3538976 | - | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
NCTC86EC_RS17415 | 3539128..3539787 | + | 660 | WP_001221493.1 | two-component system response regulator QseB | - |
NCTC86EC_RS17420 | 3539784..3541133 | + | 1350 | WP_000673402.1 | two-component system sensor histidine kinase QseC | - |
NCTC86EC_RS17425 | 3541179..3541511 | - | 333 | WP_000917684.1 | DUF2645 family protein | - |
NCTC86EC_RS17430 | 3541830..3542411 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
NCTC86EC_RS17435 | 3542442..3542756 | + | 315 | WP_000958598.1 | antibiotic biosynthesis monooxygenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T293277 WP_000415584.1 NZ_LT601384:c3537844-3537548 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT293277 WP_000650107.1 NZ_LT601384:c3537546-3537151 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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