Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3537151..3537844 Replicon chromosome
Accession NZ_LT601384
Organism Escherichia coli isolate NCTC86EC

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NCTC86EC_RS17400 Protein ID WP_000415584.1
Coordinates 3537548..3537844 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NCTC86EC_RS17395 Protein ID WP_000650107.1
Coordinates 3537151..3537546 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC86EC_RS17385 3533015..3535273 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
NCTC86EC_RS17390 3535411..3537018 - 1608 WP_021561146.1 ABC transporter substrate-binding protein -
NCTC86EC_RS17395 3537151..3537546 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NCTC86EC_RS17400 3537548..3537844 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NCTC86EC_RS17405 3538049..3538531 - 483 WP_000183505.1 transcriptional regulator -
NCTC86EC_RS17410 3538584..3538976 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NCTC86EC_RS17415 3539128..3539787 + 660 WP_001221493.1 two-component system response regulator QseB -
NCTC86EC_RS17420 3539784..3541133 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
NCTC86EC_RS17425 3541179..3541511 - 333 WP_000917684.1 DUF2645 family protein -
NCTC86EC_RS17430 3541830..3542411 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NCTC86EC_RS17435 3542442..3542756 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T293277 WP_000415584.1 NZ_LT601384:c3537844-3537548 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT293277 WP_000650107.1 NZ_LT601384:c3537546-3537151 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References