Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 848340..848842 Replicon chromosome
Accession NZ_LT601384
Organism Escherichia coli isolate NCTC86EC

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NCTC86EC_RS03890 Protein ID WP_000767829.1
Coordinates 848588..848842 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NCTC86EC_RS03885 Protein ID WP_001259255.1
Coordinates 848340..848591 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCTC86EC_RS03865 843518..844585 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NCTC86EC_RS03870 844585..845655 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NCTC86EC_RS03875 845658..846956 - 1299 WP_001743908.1 histidinol dehydrogenase -
NCTC86EC_RS03880 846962..847861 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NCTC86EC_RS25565 848007..848057 - 51 WP_001364200.1 his operon leader peptide -
NCTC86EC_RS03885 848340..848591 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NCTC86EC_RS03890 848588..848842 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NCTC86EC_RS03895 848925..849749 + 825 WP_000754762.1 SDR family oxidoreductase -
NCTC86EC_RS03900 849795..850724 + 930 WP_000803360.1 LysR family transcriptional regulator -
NCTC86EC_RS28225 850939..851001 + 63 WP_010723108.1 membrane protein YoeI -
NCTC86EC_RS03905 850991..852349 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NCTC86EC_RS03910 852528..853586 + 1059 WP_000492305.1 transport protein YeeE -
NCTC86EC_RS03915 853600..853827 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293259 WP_000767829.1 NZ_LT601384:848588-848842 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293259 WP_001259255.1 NZ_LT601384:848340-848591 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References