Detailed information of TA system TA293254

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2269640..2269857
• Replicon: chromosome
• Accession: NZ_LT598688
• Organism: Staphylococcus aureus isolate Sa_Newman_UoM

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: BN8422_RS11850
• Protein ID: WP_001802298.1
• Coordinates: 2269753..2269857 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2269640..2269695 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN8422_RS11830	2265843..2266508	-	666	WP_001024094.1	SDR family oxidoreductase	-
BN8422_RS11835	2266660..2266980	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
BN8422_RS11840	2266982..2267962	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
BN8422_RS11845	2268228..2269319	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2269640..2269695	+	56	-	-	Antitoxin
BN8422_RS11850	2269753..2269857	-	105	WP_001802298.1	hypothetical protein	Toxin
BN8422_RS15735	2270018..2270501	-	484	Protein_2249	recombinase family protein	-
BN8422_RS11860	2270544..2271680	-	1137	WP_000115564.1	SAP domain-containing protein	-
BN8422_RS11865	2271969..2272061	+	93	WP_001790138.1	hypothetical protein	-
BN8422_RS11870	2272766..2273623	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
BN8422_RS11875	2273691..2274473	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T293254 WP_001802298.1 NZ_LT598688:c2269857-2269753 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT293254 NZ_LT598688:2269640-2269695 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin