293238

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2536480..2537723 Replicon chromosome
Accession NZ_LT598657
Organism Legionella pneumophila strain Lpm7613 isolate Lpm7613

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag LPM7613_RS11170 Protein ID WP_010948074.1
Coordinates 2536785..2537723 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag LPM7613_RS11165 Protein ID WP_010948073.1
Coordinates 2536480..2536788 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPM7613_RS11140 2531916..2532281 + 366 WP_010948069.1 BRCT domain-containing protein -
LPM7613_RS11145 2532638..2533003 - 366 WP_010948070.1 TraK family protein -
LPM7613_RS15640 2533188..2533328 - 141 WP_153802426.1 hypothetical protein -
LPM7613_RS11150 2533331..2535082 - 1752 WP_010948071.1 DUF927 domain-containing protein -
LPM7613_RS11155 2535148..2535423 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
LPM7613_RS11160 2536256..2536483 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
LPM7613_RS11165 2536480..2536788 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
LPM7613_RS11170 2536785..2537723 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
LPM7613_RS11175 2538266..2538880 + 615 WP_010948075.1 hypothetical protein -
LPM7613_RS11180 2539036..2539242 - 207 WP_015444115.1 hypothetical protein -
LPM7613_RS11185 2539579..2540847 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
LPM7613_RS11190 2541063..2541588 - 526 Protein_2186 hypothetical protein -
LPM7613_RS11195 2541588..2542253 - 666 WP_015444114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T293238 WP_010948074.1 NZ_LT598657:2536785-2537723 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT293238 WP_010948073.1 NZ_LT598657:2536480-2536788 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
AlphaFold DB Q5ZSZ7

References