Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4115756..4116449 Replicon chromosome
Accession NZ_LT594504
Organism Escherichia coli isolate E. coli RL465

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag RL465_RS19865 Protein ID WP_000415585.1
Coordinates 4116153..4116449 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag RL465_RS19860 Protein ID WP_000650107.1
Coordinates 4115756..4116151 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL465_RS19850 4111620..4113878 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
RL465_RS19855 4114016..4115623 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
RL465_RS19860 4115756..4116151 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
RL465_RS19865 4116153..4116449 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
RL465_RS19870 4116654..4117136 - 483 WP_000183505.1 transcriptional regulator -
RL465_RS19875 4117189..4117581 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
RL465_RS19880 4117733..4118392 + 660 WP_001221502.1 two-component system response regulator QseB -
RL465_RS19885 4118389..4119738 + 1350 WP_000673358.1 two-component system sensor histidine kinase QseC -
RL465_RS19890 4119784..4120116 - 333 WP_000914690.1 DUF2645 family protein -
RL465_RS19895 4120123..4121315 - 1193 Protein_3887 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T293226 WP_000415585.1 NZ_LT594504:c4116449-4116153 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT293226 WP_000650107.1 NZ_LT594504:c4116151-4115756 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References