Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2992076..2992578 Replicon chromosome
Accession NZ_LT594504
Organism Escherichia coli isolate E. coli RL465

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag RL465_RS14625 Protein ID WP_000767829.1
Coordinates 2992076..2992330 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag RL465_RS14630 Protein ID WP_001259255.1
Coordinates 2992327..2992578 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL465_RS14595 2987091..2987318 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
RL465_RS14600 2987332..2988390 - 1059 WP_000492346.1 transport protein YeeE -
RL465_RS14605 2988569..2989927 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
RL465_RS14610 2989917..2989979 - 63 WP_010723108.1 membrane protein YoeI -
RL465_RS14615 2990194..2991123 - 930 WP_000803351.1 LysR family transcriptional regulator -
RL465_RS14620 2991169..2991993 - 825 WP_000754758.1 SDR family oxidoreductase -
RL465_RS14625 2992076..2992330 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
RL465_RS14630 2992327..2992578 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
RL465_RS14635 2992862..2992912 + 51 WP_001364200.1 his operon leader peptide -
RL465_RS14640 2993058..2993957 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
RL465_RS14645 2993963..2995267 + 1305 WP_001317939.1 histidinol dehydrogenase -
RL465_RS14650 2995264..2996334 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
RL465_RS14655 2996334..2997401 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293220 WP_000767829.1 NZ_LT594504:c2992330-2992076 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293220 WP_001259255.1 NZ_LT594504:c2992578-2992327 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References