Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2607..3258 Replicon plasmid 2
Accession NZ_LT594096
Organism Acinetobacter baumannii strain BAL062

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag BAL062_RS19565 Protein ID WP_000269904.1
Coordinates 2607..2963 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BAL062_RS19570 Protein ID WP_001129974.1
Coordinates 2956..3258 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAL062_RS19550 1..936 + 936 WP_001292329.1 replication initiation protein RepM -
BAL062_RS19555 1014..1532 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
BAL062_RS19560 1742..2041 + 300 WP_000358348.1 hypothetical protein -
BAL062_RS19565 2607..2963 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BAL062_RS19570 2956..3258 + 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
BAL062_RS19575 3251..3460 + 210 WP_000069474.1 hypothetical protein -
BAL062_RS19580 3786..4247 - 462 WP_000761346.1 DIP1984 family protein -
BAL062_RS19585 4552..5112 - 561 Protein_7 TonB-dependent receptor -
BAL062_RS19590 5162..5923 - 762 WP_000425105.1 hypothetical protein -
BAL062_RS19595 6228..7397 + 1170 WP_002134206.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8015 8015


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T293211 WP_000269904.1 NZ_LT594096:2607-2963 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT293211 WP_001129974.1 NZ_LT594096:2956-3258 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References