Detailed information of TA system TA293161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 40943..41456
• Replicon: chromosome
• Accession: NZ_LT571449
• Organism: Staphylococcus epidermidis isolate BPH0662

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A8X8K3D7
• Locus tag: BN6763_RS00265
• Protein ID: WP_002504630.1
• Coordinates: 41190..41456 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A8X8K5E4
• Locus tag: BN6763_RS00260
• Protein ID: WP_002504631.1
• Coordinates: 40943..41197 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN6763_RS00230	37396..38613	+	1218	WP_002504637.1	restriction endonuclease subunit S	-
BN6763_RS00235	38659..39057	+	399	WP_002504636.1	hypothetical protein	-
BN6763_RS00240	39207..39428	-	222	WP_002504635.1	hypothetical protein	-
BN6763_RS00245	39443..39823	-	381	Protein_29	DUF1643 domain-containing protein	-
BN6763_RS00250	39799..40233	+	435	WP_002504633.1	hypothetical protein	-
BN6763_RS00255	40343..40879	+	537	WP_002504632.1	hypothetical protein	-
BN6763_RS00260	40943..41197	+	255	WP_002504631.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BN6763_RS00265	41190..41456	+	267	WP_002504630.1	Txe/YoeB family addiction module toxin	Toxin
BN6763_RS00270	41495..42097	-	603	WP_002504629.1	hypothetical protein	-
BN6763_RS00275	42251..42838	-	588	WP_002504627.1	AAA family ATPase	-
BN6763_RS00280	42980..43573	-	594	WP_142925665.1	hypothetical protein	-
BN6763_RS00285	43668..44318	-	651	WP_002505564.1	hypothetical protein	-
BN6763_RS00290	44735..45247	+	513	WP_002505565.1	hypothetical protein	-
BN6763_RS00295	45284..45847	+	564	WP_002504585.1	DUF805 domain-containing protein	-
BN6763_RS00300	45847..46416	+	570	WP_002504584.1	DUF805 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10520.21 Da
• Isoelectric Point: 10.1013

>T293161 WP_002504630.1 NZ_LT571449:41190-41456 [Staphylococcus epidermidis]
MNKYNVTFTPTAFEDYKYWQKQDKKLLKKINSLIKSIQRDGILEGEGKPEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY

Nucleotide

• Length: 267 bp

>T293161 NZ_LT571449:41190-41456 [Staphylococcus epidermidis]
ATGAATAAGTACAATGTTACGTTCACACCTACAGCTTTTGAAGACTATAAGTATTGGCAAAAACAAGATAAAAAACTATT
AAAGAAAATTAATAGTTTGATTAAGAGTATTCAAAGAGATGGCATTTTAGAGGGTGAAGGTAAGCCTGAGCCATTGAAAG
GTAACTTGAAAGGTTACTATAGTAGAAGAATAAACCATGAACATAGATTAGTTTATACAATCAAAGACCCTAGTATTATA
ATCATTGCATGTAGATATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9590.51 Da
• Isoelectric Point: 4.0717

>AT293161 WP_002504631.1 NZ_LT571449:40943-41197 [Staphylococcus epidermidis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDHNAVLMSEDDYNSIMETLYLQQSPANAKRLAQSIEEAERGNTVEVDI
ETYE

Nucleotide

• Length: 255 bp

>AT293161 NZ_LT571449:40943-41197 [Staphylococcus epidermidis]
ATGACTGTTCTAACATACTCAAATGCACGTAAGGATTTCCGAAAATTAATAGATAAAGTGAATGATGATAGTGATACTGT
AACTATCACAACAAACGACCATAACGCTGTATTGATGAGTGAAGATGATTATAATTCAATTATGGAAACACTCTACTTAC
AACAATCACCAGCCAATGCTAAACGTTTAGCTCAATCAATAGAAGAAGCTGAAAGAGGTAATACTGTAGAGGTAGATATA
GAAACTTATGAATAA