Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3136983..3137545 Replicon chromosome
Accession NZ_LT556084
Organism Citrobacter amalonaticus strain 86

Toxin (Protein)


Gene name higB Uniprot ID A0A8B3ZQU4
Locus tag CITRO86_RS15660 Protein ID WP_044267611.1
Coordinates 3137267..3137545 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CITRO86_RS15655 Protein ID WP_043000693.1
Coordinates 3136983..3137267 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO86_RS15640 3134676..3135560 + 885 WP_043000690.1 formate dehydrogenase subunit beta -
CITRO86_RS15645 3135553..3136209 + 657 WP_043000691.1 formate dehydrogenase-N subunit gamma -
CITRO86_RS15650 3136336..3136938 + 603 WP_109740240.1 inorganic diphosphatase -
CITRO86_RS15655 3136983..3137267 - 285 WP_043000693.1 HigA family addiction module antidote protein Antitoxin
CITRO86_RS15660 3137267..3137545 - 279 WP_044267611.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CITRO86_RS15665 3137725..3139440 - 1716 WP_109740239.1 ATP-binding cassette domain-containing protein -
CITRO86_RS15670 3139749..3141446 - 1698 WP_044257943.1 malate dehydrogenase -
CITRO86_RS15675 3141618..3141761 - 144 WP_042319017.1 stationary-phase-induced ribosome-associated protein -
CITRO86_RS15680 3141989..3142420 + 432 WP_043000697.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10507.00 Da        Isoelectric Point: 8.1206

>T293140 WP_044267611.1 NZ_LT556084:c3137545-3137267 [Citrobacter amalonaticus]
MIINFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSGNWRMTFEFVN
GDAYILDDEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10370.07 Da        Isoelectric Point: 10.2982

>AT293140 WP_043000693.1 NZ_LT556084:c3137267-3136983 [Citrobacter amalonaticus]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3ZQU4

Antitoxin

Source ID Structure

References