Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2469237..2469759 Replicon chromosome
Accession NZ_LT220504
Organism Lacticaseibacillus rhamnosus strain BPL5

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag BN3853_RS11535 Protein ID WP_005687756.1
Coordinates 2469237..2469497 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag BN3853_RS11540 Protein ID WP_005687754.1
Coordinates 2469490..2469759 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN3853_RS11510 2464653..2465294 + 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
BN3853_RS11515 2465362..2466141 + 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
BN3853_RS11520 2466326..2467213 + 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
BN3853_RS11525 2467280..2468101 - 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
BN3853_RS11530 2468298..2469026 + 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
BN3853_RS11535 2469237..2469497 - 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
BN3853_RS11540 2469490..2469759 - 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BN3853_RS11545 2470385..2471185 + 801 WP_005690776.1 SDR family oxidoreductase -
BN3853_RS11550 2471212..2473080 + 1869 WP_014571687.1 HTH domain-containing protein -
BN3853_RS11555 2473081..2473590 + 510 WP_005690780.1 transcriptional regulator GutM -
BN3853_RS11560 2473603..2474172 + 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T293115 WP_005687756.1 NZ_LT220504:c2469497-2469237 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT293115 WP_005687754.1 NZ_LT220504:c2469759-2469490 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References