Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2489606..2490123 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag NZAK3_RS12735 Protein ID WP_000113265.1
Coordinates 2489606..2489872 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NZAK3_RS12740 Protein ID WP_000584499.1
Coordinates 2489872..2490123 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS12710 2485034..2485570 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NZAK3_RS12715 2485804..2486628 - 825 WP_000572038.1 formate/nitrite transporter family protein -
NZAK3_RS12720 2486845..2487027 - 183 WP_000230292.1 hypothetical protein -
NZAK3_RS12725 2487111..2487578 - 468 WP_000153347.1 SRPBCC domain-containing protein -
NZAK3_RS12730 2487764..2489311 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NZAK3_RS15065 2489500..2489571 - 72 Protein_2412 hypothetical protein -
NZAK3_RS12735 2489606..2489872 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
NZAK3_RS12740 2489872..2490123 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NZAK3_RS12745 2490288..2490389 - 102 Protein_2415 hypothetical protein -
NZAK3_RS12750 2490396..2490995 - 600 WP_000162810.1 DsbA family protein -
NZAK3_RS12755 2491014..2491376 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NZAK3_RS12760 2491631..2492881 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
NZAK3_RS12765 2492978..2493709 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NZAK3_RS12770 2493706..2494425 - 720 WP_061713887.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T293110 WP_000113265.1 NZ_LT009690:c2489872-2489606 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT293110 WP_000584499.1 NZ_LT009690:c2490123-2489872 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References