Detailed information of TA system TA029310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2841802..2842478
• Replicon: chromosome
• Accession: NC_020990
• Organism: Streptomyces albus J1074

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: D6AZC1
• Locus tag: XNR_RS12210
• Protein ID: WP_003949888.1
• Coordinates: 2842116..2842478 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: XNR_RS12205
• Protein ID: WP_015507386.1
• Coordinates: 2841802..2842119 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XNR_RS12180	2837088..2838149	+	1062	WP_008404846.1	hypothetical protein	-
XNR_RS12185	2838365..2838895	+	531	WP_003949893.1	toxin-antitoxin system HicB family antitoxin	-
XNR_RS12190	2838997..2839866	+	870	WP_003949892.1	DUF4097 family beta strand repeat protein	-
XNR_RS12195	2839970..2840944	+	975	WP_003949891.1	daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein	-
XNR_RS12200	2840941..2841723	+	783	WP_003949890.1	ABC transporter permease	-
XNR_RS12205	2841802..2842119	-	318	WP_015507386.1	helix-turn-helix domain-containing protein	Antitoxin
XNR_RS12210	2842116..2842478	-	363	WP_003949888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XNR_RS12215	2842477..2844174	+	1698	WP_003949889.1	hypothetical protein	-
XNR_RS12220	2844264..2844506	-	243	WP_015507388.1	hypothetical protein	-
XNR_RS12225	2844810..2845664	+	855	WP_015507389.1	STAS domain-containing protein	-
XNR_RS12230	2845661..2846041	+	381	WP_003949885.1	STAS domain-containing protein	-
XNR_RS12235	2846041..2846457	+	417	WP_003949884.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-87)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13472.34 Da
• Isoelectric Point: 4.7680

>T29310 WP_003949888.1 NC_020990:c2842478-2842116 [Streptomyces albidoflavus]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQRTEWYQEAIPLAEQRYALYLKEREREEGGRP

Nucleotide

• Length: 363 bp

>T29310 NC_020990:c2842478-2842116 [Streptomyces albidoflavus]
ATGGACGGGGAATGGCAGATCTTCCTGGTTGACGAGGTGCGTGTTTGGCTCGCGTCCCTCGACGGGGCCGCGCACGCACG
AGTGGTACAGGCGCTGGACGTGCTGGCCGAGGAAGGGCCTGCTCTCGGAAGACCGCTTGTGGACACCTTGCGTGGTTCAG
CGGTGGCCAATTTGAAAGAGCTCCGGCCCGGCACGGTCAGAATCCTGTTCGCCTTCGATCCGTGGCGTTCCAGCATCTTG
CTGGTGGCAGGTGACAAGTCCGGGCAGCGGACTGAGTGGTACCAGGAGGCGATCCCCCTGGCCGAGCAGCGCTACGCGCT
TTACTTGAAGGAACGTGAGCGGGAAGAGGGAGGACGACCATGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11572.07 Da
• Isoelectric Point: 9.8236

>AT29310 WP_015507386.1 NC_020990:c2842119-2841802 [Streptomyces albidoflavus]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRISQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Nucleotide

• Length: 318 bp

>AT29310 NC_020990:c2842119-2841802 [Streptomyces albidoflavus]
ATGACGAGTTACACCCGTTGGCAGGACATTCGTCCCGAGCATGTCGCCCGCGCAGGGGGTGAGGAAGCCGTACGCGCGGG
TAAGGAGGAGCTGCTCGCGCAGGTCACCGGGAGGAAGCTCGCGGAGCTGCGTCGCGCCCGAGGGCTGACCCAGCAGGAGG
TGGCGGACCGGATGGGGGTCAGCAAGGGGCGGATCTCCCAGATCGAGCGGGGGCACCTTTCGGGACAGGAAGTGCTGGCC
CGATTCGCGACCGCTCTCGGAGGCCGTCTCCATCAGGCGATCTACTTCGACGACGGCGACATCGCCACCATCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A7Y6SI38