Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4814559..4815161 Replicon chromosome
Accession NZ_LS999560
Organism Escherichia coli isolate EC-TO143

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag ECTO143_RS23895 Protein ID WP_000897302.1
Coordinates 4814850..4815161 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ECTO143_RS23890 Protein ID WP_000356397.1
Coordinates 4814559..4814849 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO143_RS23850 4809866..4810795 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
ECTO143_RS23855 4810977..4811219 - 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
ECTO143_RS23860 4811509..4812357 + 849 WP_001038650.1 hypothetical protein -
ECTO143_RS23865 4812673..4813122 + 450 WP_032140890.1 hypothetical protein -
ECTO143_RS23870 4813307..4813525 - 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
ECTO143_RS23880 4813922..4814200 - 279 WP_001296612.1 hypothetical protein -
ECTO143_RS23890 4814559..4814849 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
ECTO143_RS23895 4814850..4815161 - 312 WP_000897302.1 hypothetical protein Toxin
ECTO143_RS23900 4815390..4816298 + 909 WP_001385591.1 alpha/beta hydrolase -
ECTO143_RS23905 4816362..4817303 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
ECTO143_RS23910 4817348..4817785 - 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
ECTO143_RS23915 4817782..4818654 - 873 WP_000920762.1 virulence factor BrkB family protein -
ECTO143_RS23920 4818648..4819247 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T293081 WP_000897302.1 NZ_LS999560:c4815161-4814850 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT293081 WP_000356397.1 NZ_LS999560:c4814849-4814559 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References