Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5391439..5392034 Replicon chromosome
Accession NC_020912
Organism Pseudomonas aeruginosa B136-33

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G655_RS30435 Protein ID WP_015503682.1
Coordinates 5391756..5392034 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G655_RS24730 Protein ID WP_003133769.1
Coordinates 5391439..5391744 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G655_RS24695 5386580..5387428 + 849 WP_015503681.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
G655_RS24705 5387595..5388536 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
G655_RS24710 5388653..5389267 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
G655_RS24715 5389309..5389893 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
G655_RS24720 5389934..5391034 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
G655_RS24730 5391439..5391744 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
G655_RS30435 5391756..5392034 - 279 WP_015503682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G655_RS24735 5392363..5394591 + 2229 WP_015503683.1 TonB-dependent receptor -
G655_RS24740 5394661..5395308 - 648 WP_003095021.1 carbonate dehydratase -
G655_RS24745 5395370..5396608 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10563.12 Da        Isoelectric Point: 7.2157

>T29308 WP_015503682.1 NC_020912:c5392034-5391756 [Pseudomonas aeruginosa B136-33]
MILTFCCDETRQLFEAGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T29308 NC_020912:c5392034-5391756 [Pseudomonas aeruginosa B136-33]
ATGATTCTGACCTTTTGCTGCGACGAGACTCGTCAGCTTTTTGAGGCGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAACGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT29308 WP_003133769.1 NC_020912:c5391744-5391439 [Pseudomonas aeruginosa B136-33]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT29308 NC_020912:c5391744-5391439 [Pseudomonas aeruginosa B136-33]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTCGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References