Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3722049..3722724 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag ECLTO80_RS18255 Protein ID WP_015571638.1
Coordinates 3722049..3722348 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag ECLTO80_RS18260 Protein ID WP_015571639.1
Coordinates 3722359..3722724 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS18245 3718426..3720618 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
ECLTO80_RS18250 3720638..3721798 + 1161 WP_085929677.1 HlyD family efflux transporter periplasmic adaptor subunit -
ECLTO80_RS18255 3722049..3722348 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECLTO80_RS18260 3722359..3722724 + 366 WP_015571639.1 HigA family addiction module antidote protein Antitoxin
ECLTO80_RS18265 3722751..3723932 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
ECLTO80_RS18270 3723953..3724840 - 888 WP_015571641.1 LysR family transcriptional regulator -
ECLTO80_RS18275 3724938..3725540 + 603 WP_017382759.1 short chain dehydrogenase -
ECLTO80_RS18280 3725537..3726268 - 732 WP_039269965.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T293055 WP_015571638.1 NZ_LS999206:3722049-3722348 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT293055 WP_015571639.1 NZ_LS999206:3722359-3722724 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References