Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2975203..2975705 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name yoeB Uniprot ID A0A235EZL9
Locus tag ECLTO80_RS14755 Protein ID WP_075117074.1
Coordinates 2975203..2975457 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A235F1E0
Locus tag ECLTO80_RS14760 Protein ID WP_075117073.1
Coordinates 2975454..2975705 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS14730 2970721..2971584 + 864 WP_094267734.1 integrase domain-containing protein -
ECLTO80_RS14735 2971592..2972389 - 798 WP_102053793.1 hypothetical protein -
ECLTO80_RS14740 2972763..2973053 + 291 WP_197731404.1 hypothetical protein -
ECLTO80_RS14745 2973069..2974589 + 1521 WP_102053794.1 conjugal transfer protein TraG N-terminal domain-containing protein -
ECLTO80_RS14750 2974597..2974986 - 390 WP_075117075.1 DUF3742 family protein -
ECLTO80_RS14755 2975203..2975457 - 255 WP_075117074.1 Txe/YoeB family addiction module toxin Toxin
ECLTO80_RS14760 2975454..2975705 - 252 WP_075117073.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECLTO80_RS14765 2975803..2977170 - 1368 WP_075117072.1 tyrosine-type recombinase/integrase -
ECLTO80_RS14775 2977635..2978183 - 549 WP_003859652.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
ECLTO80_RS14780 2978240..2980072 - 1833 WP_017384477.1 excinuclease ABC subunit UvrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / qacE / blaOXA-2 / ant(3'')-Ia / blaGIM-1 - 2944865..2977170 32305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.65 Da        Isoelectric Point: 9.4089

>T293052 WP_075117074.1 NZ_LS999206:c2975457-2975203 [Enterobacter hormaechei]
VKLIWSEQAWDDYLYWQEADKRMVKKLNELIKETRRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDEALLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9391.61 Da        Isoelectric Point: 4.5843

>AT293052 WP_075117073.1 NZ_LS999206:c2975705-2975454 [Enterobacter hormaechei]
MRTISYTEARQNLSATMVQTVEDRVPTLITRQNGEACVLMSLEEYNALEETAYLLRSPANARRLMDSIDSLKRGQGVERD
IAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A235EZL9

Antitoxin

Source ID Structure
AlphaFold DB A0A235F1E0

References