Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 31734..32464 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag ECLTO80_RS00155 Protein ID WP_023302825.1
Coordinates 31734..32048 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ECLTO80_RS00160 Protein ID WP_023323924.1
Coordinates 32045..32464 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS00130 27400..28485 + 1086 Protein_25 cellulase family glycosylhydrolase -
ECLTO80_RS00135 28391..29575 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
ECLTO80_RS00140 29751..30584 - 834 WP_133982172.1 DMT family transporter -
ECLTO80_RS00145 30647..31093 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
ECLTO80_RS00150 31158..31247 - 90 WP_017383683.1 type I toxin-antitoxin system toxin TisB -
ECLTO80_RS00155 31734..32048 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
ECLTO80_RS00160 32045..32464 + 420 WP_023323924.1 helix-turn-helix domain-containing protein Antitoxin
ECLTO80_RS00165 32611..32709 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
ECLTO80_RS00170 32816..34504 + 1689 WP_015570114.1 acetolactate synthase large subunit -
ECLTO80_RS00175 34508..34795 + 288 WP_015570113.1 acetolactate synthase small subunit -
ECLTO80_RS00180 34921..35514 + 594 WP_003861054.1 transcriptional regulator UhpA -
ECLTO80_RS00185 35511..37016 + 1506 WP_133982174.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(1-139)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T293041 WP_023302825.1 NZ_LS999206:31734-32048 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15499.15 Da        Isoelectric Point: 5.7670

>AT293041 WP_023323924.1 NZ_LS999206:32045-32464 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISRYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure

References