Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6096993..6097588 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PA5486_RS29965 Protein ID WP_003117425.1
Coordinates 6097310..6097588 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PA5486_RS29960 Protein ID WP_003099268.1
Coordinates 6096993..6097298 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS29925 6093636..6093911 - 276 WP_033896065.1 mercury resistance system periplasmic binding protein MerP -
PA5486_RS29930 6093927..6094277 - 351 WP_001294660.1 mercuric transport protein MerT -
PA5486_RS29935 6094349..6094804 + 456 WP_033896066.1 Hg(II)-responsive transcriptional regulator -
PA5486_RS29940 6095166..6095942 - 777 WP_033896079.1 hypothetical protein -
PA5486_RS29945 6095967..6096080 - 114 Protein_5760 RepA -
PA5486_RS29950 6096119..6096331 - 213 WP_025297679.1 AlpA family phage regulatory protein -
PA5486_RS29960 6096993..6097298 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
PA5486_RS29965 6097310..6097588 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PA5486_RS29975 6097913..6100141 + 2229 WP_003113525.1 TonB-dependent receptor -
PA5486_RS29980 6100211..6100858 - 648 WP_003095021.1 carbonate dehydratase -
PA5486_RS29985 6100920..6102158 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T293007 WP_003117425.1 NZ_LS998783:c6097588-6097310 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT293007 WP_003099268.1 NZ_LS998783:c6097298-6096993 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References