Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2588624..2589126 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name yoeB Uniprot ID A0A235EZL9
Locus tag PA5486_RS12730 Protein ID WP_075117074.1
Coordinates 2588872..2589126 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A235F1E0
Locus tag PA5486_RS12725 Protein ID WP_075117073.1
Coordinates 2588624..2588875 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS12690 2584413..2584895 + 483 WP_003090905.1 GAF domain-containing protein -
PA5486_RS12695 2584905..2585567 - 663 WP_003098798.1 glutathione S-transferase family protein -
PA5486_RS12700 2585629..2586402 - 774 WP_003090903.1 hypothetical protein -
PA5486_RS12720 2587159..2588526 + 1368 WP_075117072.1 tyrosine-type recombinase/integrase -
PA5486_RS12725 2588624..2588875 + 252 WP_075117073.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PA5486_RS12730 2588872..2589126 + 255 WP_075117074.1 Txe/YoeB family addiction module toxin Toxin
PA5486_RS12735 2589343..2589732 + 390 WP_075117075.1 DUF3742 family protein -
PA5486_RS12740 2589740..2591260 - 1521 WP_102053794.1 conjugal transfer protein TraG N-terminal domain-containing protein -
PA5486_RS12745 2591276..2591626 - 351 WP_094267732.1 hypothetical protein -
PA5486_RS12755 2591879..2592907 + 1029 WP_034023821.1 IS30 family transposase -
PA5486_RS12760 2593056..2593853 + 798 WP_102053793.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2591879..2592907 1028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.65 Da        Isoelectric Point: 9.4089

>T293002 WP_075117074.1 NZ_LS998783:2588872-2589126 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQEADKRMVKKLNELIKETRRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDEALLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9391.61 Da        Isoelectric Point: 4.5843

>AT293002 WP_075117073.1 NZ_LS998783:2588624-2588875 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMVQTVEDRVPTLITRQNGEACVLMSLEEYNALEETAYLLRSPANARRLMDSIDSLKRGQGVERD
IAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A235EZL9

Antitoxin

Source ID Structure
AlphaFold DB A0A235F1E0

References