292943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1932558..1933060 Replicon chromosome
Accession NZ_LS992192
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag ECTO217_RS09305 Protein ID WP_000767819.1
Coordinates 1932806..1933060 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag ECTO217_RS09300 Protein ID WP_001259253.1
Coordinates 1932558..1932809 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS09270 1927736..1928803 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
ECTO217_RS09275 1928803..1929873 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
ECTO217_RS09280 1929870..1931174 - 1305 WP_001296211.1 histidinol dehydrogenase -
ECTO217_RS09285 1931180..1932079 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECTO217_RS09290 1932225..1932275 - 51 WP_001364200.1 his operon leader peptide -
ECTO217_RS09300 1932558..1932809 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECTO217_RS09305 1932806..1933060 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECTO217_RS09310 1933143..1933967 + 825 WP_000754737.1 SDR family oxidoreductase -
ECTO217_RS09315 1934013..1934942 + 930 WP_000803366.1 LysR family transcriptional regulator -
ECTO217_RS09320 1935157..1935219 + 63 WP_010723108.1 membrane protein YoeI -
ECTO217_RS09325 1935209..1936567 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
ECTO217_RS09335 1936784..1937242 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1936784..1937242 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T292943 WP_000767819.1 NZ_LS992192:1932806-1933060 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT292943 WP_001259253.1 NZ_LS992192:1932558-1932809 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References