Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4914363..4914965 | Replicon | chromosome |
Accession | NZ_LS992190 | ||
Organism | Escherichia coli isolate Escherichia coli str. TO148 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | ECTO148_RS24525 | Protein ID | WP_000897302.1 |
Coordinates | 4914654..4914965 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | ECTO148_RS24520 | Protein ID | WP_000356397.1 |
Coordinates | 4914363..4914653 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECTO148_RS24480 | 4909670..4910599 | + | 930 | WP_000027696.1 | formate dehydrogenase accessory protein FdhE | - |
ECTO148_RS24485 | 4910781..4911023 | - | 243 | WP_001068514.1 | ribbon-helix-helix domain-containing protein | - |
ECTO148_RS24490 | 4911313..4912161 | + | 849 | WP_001038650.1 | hypothetical protein | - |
ECTO148_RS24495 | 4912477..4912926 | + | 450 | WP_032140890.1 | hypothetical protein | - |
ECTO148_RS24500 | 4913111..4913329 | - | 219 | WP_001251293.1 | ribbon-helix-helix domain-containing protein | - |
ECTO148_RS24510 | 4913726..4914004 | - | 279 | WP_001296612.1 | hypothetical protein | - |
ECTO148_RS24520 | 4914363..4914653 | - | 291 | WP_000356397.1 | helix-turn-helix domain-containing protein | Antitoxin |
ECTO148_RS24525 | 4914654..4914965 | - | 312 | WP_000897302.1 | hypothetical protein | Toxin |
ECTO148_RS24530 | 4915194..4916102 | + | 909 | WP_001385591.1 | alpha/beta hydrolase | - |
ECTO148_RS24535 | 4916166..4917107 | - | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
ECTO148_RS24540 | 4917152..4917589 | - | 438 | WP_000560981.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
ECTO148_RS24545 | 4917586..4918458 | - | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
ECTO148_RS24550 | 4918452..4919051 | - | 600 | WP_001296610.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T292933 WP_000897302.1 NZ_LS992190:c4914965-4914654 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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