Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4214815..4215508 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EC3426_RS20660 Protein ID WP_000415584.1
Coordinates 4215212..4215508 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EC3426_RS20655 Protein ID WP_000650107.1
Coordinates 4214815..4215210 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS20645 4210679..4212937 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
EC3426_RS20650 4213075..4214682 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EC3426_RS20655 4214815..4215210 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EC3426_RS20660 4215212..4215508 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EC3426_RS20665 4215713..4216195 - 483 WP_000183505.1 transcriptional regulator -
EC3426_RS20670 4216248..4216640 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EC3426_RS20675 4216792..4217451 + 660 WP_001221493.1 two-component system response regulator QseB -
EC3426_RS20680 4217448..4218797 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
EC3426_RS20685 4218843..4219175 - 333 WP_023149630.1 DUF2645 family protein -
EC3426_RS20690 4219494..4220075 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EC3426_RS20695 4220106..4220420 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T292889 WP_000415584.1 NZ_LS992185:c4215508-4215212 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT292889 WP_000650107.1 NZ_LS992185:c4215210-4214815 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References