Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3059911..3060413 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag EC3426_RS15180 Protein ID WP_000767831.1
Coordinates 3059911..3060165 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC3426_RS15185 Protein ID WP_001259255.1
Coordinates 3060162..3060413 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS15150 3054926..3055153 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
EC3426_RS15155 3055167..3056225 - 1059 WP_000492321.1 transport protein YeeE -
EC3426_RS15160 3056404..3057762 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC3426_RS15165 3057752..3057814 - 63 WP_010723108.1 membrane protein YoeI -
EC3426_RS15170 3058029..3058958 - 930 WP_024195433.1 LysR family transcriptional regulator -
EC3426_RS15175 3059004..3059828 - 825 WP_000754737.1 SDR family oxidoreductase -
EC3426_RS15180 3059911..3060165 - 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC3426_RS15185 3060162..3060413 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC3426_RS15190 3060697..3060747 + 51 WP_001364200.1 his operon leader peptide -
EC3426_RS15195 3060893..3061792 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC3426_RS15200 3061798..3063102 + 1305 WP_001446927.1 histidinol dehydrogenase -
EC3426_RS15205 3063099..3064169 + 1071 WP_000108945.1 histidinol-phosphate transaminase -
EC3426_RS15210 3064169..3065236 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T292885 WP_000767831.1 NZ_LS992185:c3060165-3059911 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292885 WP_001259255.1 NZ_LS992185:c3060413-3060162 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References