292877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2000257..2001052 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag EC3426_RS09680 Protein ID WP_000854914.1
Coordinates 2000678..2001052 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag EC3426_RS09675 Protein ID WP_001280955.1
Coordinates 2000257..2000631 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS09640 1995612..1996517 + 906 WP_023149949.1 hypothetical protein -
EC3426_RS09645 1996514..1997584 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
EC3426_RS09655 1997924..1998742 + 819 WP_001234682.1 DUF945 domain-containing protein -
EC3426_RS09660 1998833..1999318 + 486 WP_000214398.1 antirestriction protein -
EC3426_RS09665 1999334..1999810 + 477 WP_001186738.1 RadC family protein -
EC3426_RS09670 1999873..2000094 + 222 WP_001220314.1 DUF987 domain-containing protein -
EC3426_RS09675 2000257..2000631 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC3426_RS09680 2000678..2001052 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
EC3426_RS09685 2001049..2001540 + 492 WP_000976857.1 hypothetical protein -
EC3426_RS09690 2001552..2001749 + 198 WP_000839282.1 DUF957 domain-containing protein -
EC3426_RS09695 2001834..2002676 + 843 WP_001280481.1 DUF4942 domain-containing protein -
EC3426_RS09705 2003147..2004085 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
EC3426_RS09710 2004140..2004877 + 738 WP_000283667.1 zinc-binding phosphatase -
EC3426_RS09715 2004901..2005455 + 555 WP_001001921.1 molecular chaperone YcdY -
EC3426_RS09720 2005557..2006048 + 492 WP_001300785.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1999334..2011614 12280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T292877 WP_000854914.1 NZ_LS992185:2000678-2001052 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT292877 WP_001280955.1 NZ_LS992185:2000257-2000631 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References