Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1025883..1026424 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag EC3426_RS04865 Protein ID WP_000615983.1
Coordinates 1025883..1026161 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag EC3426_RS04870 Protein ID WP_000729703.1
Coordinates 1026164..1026424 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS04850 1023465..1024043 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
EC3426_RS04855 1024249..1025016 + 768 WP_000333380.1 class II glutamine amidotransferase -
EC3426_RS04860 1024987..1025727 - 741 WP_001225679.1 murein L,D-transpeptidase -
EC3426_RS04865 1025883..1026161 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EC3426_RS04870 1026164..1026424 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EC3426_RS04875 1026634..1027383 + 750 WP_000056849.1 C40 family peptidase -
EC3426_RS04880 1027559..1028056 + 498 WP_060581685.1 REP-associated tyrosine transposase RayT -
EC3426_RS04885 1028280..1029992 - 1713 Protein_924 flagellar biosynthesis protein FlhA -
EC3426_RS04890 1029964..1030749 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T292873 WP_000615983.1 NZ_LS992185:c1026161-1025883 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT292873 WP_000729703.1 NZ_LS992185:c1026424-1026164 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References