Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4629068..4629738 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFU2785_RS23100 Protein ID WP_134216415.1
Coordinates 4629068..4629370 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFU2785_RS23105 Protein ID WP_046671375.1
Coordinates 4629397..4629738 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS23080 4624611..4626134 - 1524 WP_003031804.1 sugar ABC transporter ATP-binding protein -
CFU2785_RS23090 4626249..4628513 + 2265 WP_134216414.1 hybrid sensor histidine kinase/response regulator -
CFU2785_RS23095 4628583..4628912 + 330 WP_003031807.1 hypothetical protein -
CFU2785_RS23100 4629068..4629370 + 303 WP_134216415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFU2785_RS23105 4629397..4629738 + 342 WP_046671375.1 HigA family addiction module antidote protein Antitoxin
CFU2785_RS23110 4629791..4630549 - 759 WP_134216416.1 phosphonate metabolism protein PhnP -
CFU2785_RS23115 4630558..4630992 - 435 WP_003031809.1 aminoalkylphosphonate N-acetyltransferase -
CFU2785_RS23120 4630979..4631533 - 555 WP_003844764.1 ribose 1,5-bisphosphokinase -
CFU2785_RS23125 4631536..4632672 - 1137 WP_003031811.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
CFU2785_RS23130 4632669..4633349 - 681 WP_134216417.1 phosphonate C-P lyase system protein PhnL -
CFU2785_RS23135 4633439..4634197 - 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11835.48 Da        Isoelectric Point: 9.9581

>T292862 WP_134216415.1 NZ_LS992183:4629068-4629370 [Citrobacter freundii]
MSKSLNIRSFRDTWLEDFFERATSHRKILADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWVNGKAEDVYLDPHIY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13017.84 Da        Isoelectric Point: 7.2040

>AT292862 WP_046671375.1 NZ_LS992183:4629397-4629738 [Citrobacter freundii]
MKQATRKPTTVGDILQYEYLEPLGLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNSESKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References