Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 43479..44127 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name higB Uniprot ID A0A0D7M266
Locus tag CFU2785_RS00210 Protein ID WP_016151211.1
Coordinates 43479..43841 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D7LEH2
Locus tag CFU2785_RS00215 Protein ID WP_003840660.1
Coordinates 43828..44127 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS00195 39938..41266 + 1329 WP_003023927.1 MFS transporter -
CFU2785_RS00200 41409..42800 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
CFU2785_RS00205 42926..43378 + 453 WP_003023933.1 DUF1198 family protein -
CFU2785_RS00210 43479..43841 + 363 WP_016151211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFU2785_RS00215 43828..44127 + 300 WP_003840660.1 helix-turn-helix transcriptional regulator Antitoxin
CFU2785_RS00220 44246..45436 + 1191 WP_032937137.1 purine ribonucleoside efflux pump NepI -
CFU2785_RS00225 45486..46868 - 1383 WP_134214804.1 glycoside hydrolase family 1 protein -
CFU2785_RS00230 46963..47256 - 294 WP_003840665.1 hypothetical protein -
CFU2785_RS00235 47387..47803 + 417 WP_003023951.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13788.66 Da        Isoelectric Point: 5.1976

>T292845 WP_016151211.1 NZ_LS992183:43479-43841 [Citrobacter freundii]
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11016.85 Da        Isoelectric Point: 8.5047

>AT292845 WP_003840660.1 NZ_LS992183:43828-44127 [Citrobacter freundii]
MATLKELMAKQSPESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7M266

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LEH2

References