292830

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4927523..4928125 Replicon chromosome
Accession NZ_LS992180
Organism Escherichia coli isolate Escherichia coli str. TO124

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag ECTO124_RS24600 Protein ID WP_000897302.1
Coordinates 4927814..4928125 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ECTO124_RS24595 Protein ID WP_000356397.1
Coordinates 4927523..4927813 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO124_RS24555 4922830..4923759 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
ECTO124_RS24560 4923941..4924183 - 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
ECTO124_RS24565 4924473..4925321 + 849 WP_001038650.1 hypothetical protein -
ECTO124_RS24570 4925637..4926086 + 450 WP_032140890.1 hypothetical protein -
ECTO124_RS24575 4926271..4926489 - 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
ECTO124_RS24585 4926886..4927164 - 279 WP_001296612.1 hypothetical protein -
ECTO124_RS24595 4927523..4927813 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
ECTO124_RS24600 4927814..4928125 - 312 WP_000897302.1 hypothetical protein Toxin
ECTO124_RS24605 4928354..4929262 + 909 WP_001385591.1 alpha/beta hydrolase -
ECTO124_RS24610 4929326..4930267 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
ECTO124_RS24615 4930312..4930749 - 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
ECTO124_RS24620 4930746..4931618 - 873 WP_000920762.1 virulence factor BrkB family protein -
ECTO124_RS24625 4931612..4932211 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T292830 WP_000897302.1 NZ_LS992180:c4928125-4927814 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT292830 WP_000356397.1 NZ_LS992180:c4927813-4927523 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References