292766

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1786028..1786530 Replicon chromosome
Accession NZ_LS992171
Organism Escherichia coli isolate Escherichia coli str. TO73

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag ECTO73_RS08470 Protein ID WP_000767831.1
Coordinates 1786276..1786530 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECTO73_RS08465 Protein ID WP_001259255.1
Coordinates 1786028..1786279 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO73_RS08440 1781205..1782272 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
ECTO73_RS08445 1782272..1783342 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
ECTO73_RS08450 1783339..1784643 - 1305 WP_001446927.1 histidinol dehydrogenase -
ECTO73_RS08455 1784649..1785548 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECTO73_RS08460 1785694..1785744 - 51 WP_001364200.1 his operon leader peptide -
ECTO73_RS08465 1786028..1786279 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECTO73_RS08470 1786276..1786530 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECTO73_RS08475 1786613..1787437 + 825 WP_000754737.1 SDR family oxidoreductase -
ECTO73_RS08480 1787483..1788412 + 930 WP_024195433.1 LysR family transcriptional regulator -
ECTO73_RS08485 1788627..1788689 + 63 WP_010723108.1 membrane protein YoeI -
ECTO73_RS08490 1788679..1790037 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECTO73_RS08495 1790216..1791274 + 1059 WP_000492321.1 transport protein YeeE -
ECTO73_RS08500 1791288..1791515 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T292766 WP_000767831.1 NZ_LS992171:1786276-1786530 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292766 WP_001259255.1 NZ_LS992171:1786028-1786279 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References