Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 599500..600299 Replicon chromosome
Accession NZ_LS992168
Organism Escherichia coli isolate Escherichia coli str. TO60

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag ECTO60_RS02965 Protein ID WP_000347251.1
Coordinates 599500..599964 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag ECTO60_RS02970 Protein ID WP_001296435.1
Coordinates 599964..600299 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO60_RS02935 594501..594935 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
ECTO60_RS02940 594953..595831 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
ECTO60_RS02945 595821..596600 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
ECTO60_RS02950 596611..597084 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
ECTO60_RS02955 597107..598387 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
ECTO60_RS02960 598636..599445 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ECTO60_RS02965 599500..599964 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECTO60_RS02970 599964..600299 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECTO60_RS02975 600448..602019 - 1572 WP_001273763.1 galactarate dehydratase -
ECTO60_RS02980 602394..603728 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
ECTO60_RS02985 603744..604514 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T292729 WP_000347251.1 NZ_LS992168:c599964-599500 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT292729 WP_001296435.1 NZ_LS992168:c600299-599964 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References