292717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3828210..3828904 Replicon chromosome
Accession NZ_LS992166
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag ECTO6_RS18885 Protein ID WP_001263489.1
Coordinates 3828210..3828608 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag ECTO6_RS18890 Protein ID WP_000554758.1
Coordinates 3828611..3828904 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- 3823798..3823878 - 81 NuclAT_11 - -
- 3823798..3823878 - 81 NuclAT_11 - -
- 3823798..3823878 - 81 NuclAT_11 - -
- 3823798..3823878 - 81 NuclAT_11 - -
ECTO6_RS18860 3824474..3824932 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
ECTO6_RS18865 3825193..3826650 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
ECTO6_RS18870 3826707..3827228 - 522 Protein_3667 peptide chain release factor H -
ECTO6_RS18875 3827224..3827430 - 207 Protein_3668 RtcB family protein -
ECTO6_RS18880 3827748..3828200 - 453 WP_001059892.1 GNAT family N-acetyltransferase -
ECTO6_RS18885 3828210..3828608 - 399 WP_001263489.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
ECTO6_RS18890 3828611..3828904 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
ECTO6_RS18895 3828956..3830011 - 1056 WP_001226164.1 DNA polymerase IV -
ECTO6_RS18900 3830082..3830867 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
ECTO6_RS18905 3830839..3832551 + 1713 Protein_3674 flagellar biosynthesis protein FlhA -
ECTO6_RS18910 3832775..3833272 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T292717 WP_001263489.1 NZ_LS992166:c3828608-3828210 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT292717 WP_000554758.1 NZ_LS992166:c3828904-3828611 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090J8B1

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References