292715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2546801..2547439 Replicon chromosome
Accession NZ_LS992166
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ECTO6_RS12575 Protein ID WP_000813794.1
Coordinates 2547263..2547439 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ECTO6_RS12570 Protein ID WP_001270286.1
Coordinates 2546801..2547217 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS12550 2541953..2542894 - 942 WP_001251304.1 ABC transporter permease -
ECTO6_RS12555 2542895..2543908 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
ECTO6_RS12560 2543926..2545071 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
ECTO6_RS12565 2545316..2546722 - 1407 WP_134091812.1 PLP-dependent aminotransferase family protein -
ECTO6_RS12570 2546801..2547217 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ECTO6_RS12575 2547263..2547439 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ECTO6_RS12580 2547661..2547891 + 231 WP_000494244.1 YncJ family protein -
ECTO6_RS12585 2547983..2549944 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ECTO6_RS12590 2550017..2550553 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
ECTO6_RS12595 2550606..2551820 + 1215 WP_071607158.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2551860..2553008 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T292715 WP_000813794.1 NZ_LS992166:c2547439-2547263 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT292715 WP_001270286.1 NZ_LS992166:c2547217-2546801 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References