Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1936581..1937083 Replicon chromosome
Accession NZ_LS992166
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECTO6_RS09445 Protein ID WP_000767829.1
Coordinates 1936829..1937083 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECTO6_RS09440 Protein ID WP_001259255.1
Coordinates 1936581..1936832 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS09415 1931759..1932826 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
ECTO6_RS09420 1932826..1933896 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECTO6_RS09425 1933893..1935197 - 1305 WP_000009594.1 histidinol dehydrogenase -
ECTO6_RS09430 1935203..1936102 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECTO6_RS09435 1936248..1936298 - 51 WP_001364200.1 his operon leader peptide -
ECTO6_RS09440 1936581..1936832 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECTO6_RS09445 1936829..1937083 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECTO6_RS09450 1937166..1937990 + 825 WP_000754737.1 SDR family oxidoreductase -
ECTO6_RS09455 1938036..1938965 + 930 WP_000803351.1 LysR family transcriptional regulator -
ECTO6_RS09460 1939180..1939242 + 63 WP_010723108.1 membrane protein YoeI -
ECTO6_RS09465 1939232..1940590 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECTO6_RS09470 1940769..1941827 + 1059 WP_000492339.1 transport protein YeeE -
ECTO6_RS09475 1941841..1942068 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T292708 WP_000767829.1 NZ_LS992166:1936829-1937083 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292708 WP_001259255.1 NZ_LS992166:1936581-1936832 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References