Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 321734..323082 Replicon chromosome
Accession NZ_LS483496
Organism Haemophilus influenzae strain NCTC8455

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag DQL17_RS01610 Protein ID WP_111688797.1
Coordinates 322051..323082 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag DQL17_RS01605 Protein ID WP_111688796.1
Coordinates 321734..322054 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL17_RS01565 317156..317434 + 279 WP_005661211.1 cell division protein FtsB -
DQL17_RS01570 317434..318111 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DQL17_RS01575 318108..318584 + 477 WP_005661209.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
DQL17_RS01580 318889..319323 - 435 WP_111688794.1 D-tyrosyl-tRNA(Tyr) deacylase -
DQL17_RS01585 319320..319760 - 441 WP_005694621.1 FMN-binding protein MioC -
DQL17_RS01590 319857..320075 - 219 WP_111688795.1 cell division protein ZapB -
DQL17_RS01595 320237..321238 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
DQL17_RS01600 321438..321746 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
DQL17_RS01605 321734..322054 + 321 WP_111688796.1 type II toxin-antitoxin system HipA family toxin Antitoxin
DQL17_RS01610 322051..323082 + 1032 WP_111688797.1 type II toxin-antitoxin system HipA family toxin Toxin
DQL17_RS01615 323166..324824 - 1659 WP_111688798.1 thiol reductant ABC exporter subunit CydC -
DQL17_RS01620 324817..326562 - 1746 WP_111688799.1 ABC transporter ATP-binding protein/permease -
DQL17_RS01625 326611..326832 - 222 WP_111688800.1 ABC transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39912.55 Da        Isoelectric Point: 6.9764

>T292662 WP_111688797.1 NZ_LS483496:322051-323082 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKTMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLHEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12471.13 Da        Isoelectric Point: 5.9670

>AT292662 WP_111688796.1 NZ_LS483496:321734-322054 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References