Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1291986..1292625 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag DQL18_RS06555 Protein ID WP_005650215.1
Coordinates 1291986..1292291 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQL18_RS06560 Protein ID WP_005650217.1
Coordinates 1292302..1292625 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS06535 1287416..1289455 - 2040 WP_038441065.1 excinuclease ABC subunit B -
DQL18_RS06545 1290070..1291038 - 969 WP_042593950.1 zinc transporter permease subunit ZevB -
DQL18_RS06550 1291041..1291661 - 621 WP_005694310.1 zinc transporter binding subunit ZevA -
DQL18_RS06555 1291986..1292291 + 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL18_RS06560 1292302..1292625 + 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
DQL18_RS06565 1292788..1294458 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
DQL18_RS06570 1294520..1294861 + 342 WP_005652996.1 SirB2 family protein -
DQL18_RS06575 1294866..1296836 + 1971 WP_105905558.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQL18_RS09810 1296833..1297006 + 174 WP_011272700.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T292650 WP_005650215.1 NZ_LS483486:1291986-1292291 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT292650 WP_005650217.1 NZ_LS483486:1292302-1292625 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References