292644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 376214..377562 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag DQL18_RS01885 Protein ID WP_105905586.1
Coordinates 376531..377562 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S9R6P7
Locus tag DQL18_RS01880 Protein ID WP_005650823.1
Coordinates 376214..376534 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS01840 371640..371918 + 279 WP_005661211.1 cell division protein FtsB -
DQL18_RS01845 371918..372595 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DQL18_RS01850 372592..373068 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
DQL18_RS01855 373373..373807 - 435 WP_013526377.1 D-tyrosyl-tRNA(Tyr) deacylase -
DQL18_RS01860 373804..374244 - 441 WP_005694621.1 FMN-binding protein MioC -
DQL18_RS01865 374341..374560 - 220 Protein_348 cell division protein ZapB -
DQL18_RS01870 374722..375723 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
DQL18_RS01875 375918..376226 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
DQL18_RS01880 376214..376534 + 321 WP_005650823.1 type II toxin-antitoxin system HipA family toxin Antitoxin
DQL18_RS01885 376531..377562 + 1032 WP_105905586.1 type II toxin-antitoxin system HipA family toxin Toxin
DQL18_RS01890 377646..379304 - 1659 WP_105905587.1 thiol reductant ABC exporter subunit CydC -
DQL18_RS01895 379297..381042 - 1746 WP_105905588.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39821.33 Da        Isoelectric Point: 6.4338

>T292644 WP_105905586.1 NZ_LS483486:376531-377562 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12404.04 Da        Isoelectric Point: 5.8850

>AT292644 WP_005650823.1 NZ_LS483486:376214-376534 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9R6P7

References