Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2570639..2571156 Replicon chromosome
Accession NZ_LS483484
Organism Staphylococcus aureus strain NCTC13277

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag DQL77_RS13330 Protein ID WP_000251928.1
Coordinates 2570639..2570905 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag DQL77_RS13335 Protein ID WP_000584497.1
Coordinates 2570905..2571156 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL77_RS13305 2565847..2566383 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
DQL77_RS13310 2566851..2567675 - 825 WP_000594640.1 formate/nitrite transporter family protein -
DQL77_RS13315 2567878..2568060 - 183 WP_000079140.1 hypothetical protein -
DQL77_RS13320 2568146..2568613 - 468 WP_000153340.1 SRPBCC domain-containing protein -
DQL77_RS13325 2568799..2570346 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DQL77_RS13330 2570639..2570905 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
DQL77_RS13335 2570905..2571156 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL77_RS13340 2571320..2571420 - 101 Protein_2481 hypothetical protein -
DQL77_RS13345 2571427..2572026 - 600 WP_000162804.1 DsbA family protein -
DQL77_RS13350 2572045..2572407 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DQL77_RS13355 2572662..2573912 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
DQL77_RS13360 2574005..2574736 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
DQL77_RS13365 2574733..2575452 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T292638 WP_000251928.1 NZ_LS483484:c2570905-2570639 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT292638 WP_000584497.1 NZ_LS483484:c2571156-2570905 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References