Detailed information of TA system TA292630

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2129573..2129880
• Replicon: chromosome
• Accession: NZ_LS483484
• Organism: Staphylococcus aureus strain NCTC13277

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DQL77_RS10880
• Protein ID: WP_011447039.1
• Coordinates: 2129704..2129880 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2129573..2129712 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL77_RS10835	2124910..2125170	+	261	WP_001791826.1	hypothetical protein	-
DQL77_RS10840	2125223..2125573	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DQL77_RS10845	2126259..2126708	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DQL77_RS10850	2126803..2127138	-	336	Protein_2017	SH3 domain-containing protein	-
DQL77_RS10860	2127788..2128279	-	492	WP_000919350.1	staphylokinase	-
DQL77_RS10865	2128471..2129226	-	756	WP_000861038.1	CHAP domain-containing protein	-
DQL77_RS10870	2129238..2129492	-	255	WP_000611512.1	phage holin	-
DQL77_RS10875	2129544..2129651	+	108	WP_001791821.1	hypothetical protein	-
-	2129573..2129712	+	140	NuclAT_0	-	Antitoxin
-	2129573..2129712	+	140	NuclAT_0	-	Antitoxin
-	2129573..2129712	+	140	NuclAT_0	-	Antitoxin
-	2129573..2129712	+	140	NuclAT_0	-	Antitoxin
DQL77_RS10880	2129704..2129880	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DQL77_RS10885	2129989..2130762	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
DQL77_RS10895	2131183..2131557	-	375	WP_000340977.1	hypothetical protein	-
DQL77_RS10900	2131613..2131900	-	288	WP_001040259.1	hypothetical protein	-
DQL77_RS10905	2131947..2132099	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2119449..2178441	58992
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2102244..2178441	76197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T292630 WP_011447039.1 NZ_LS483484:c2129880-2129704 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT292630 NZ_LS483484:2129573-2129712 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin