Detailed information of TA system TA292626

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1630489..1631068
• Replicon: chromosome
• Accession: NZ_LS483484
• Organism: Staphylococcus aureus strain NCTC13277

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DQL77_RS08100
• Protein ID: WP_001025401.1
• Coordinates: 1630823..1631068 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1630489..1630854 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL77_RS08060	1627230..1627787	-	558	WP_000645048.1	DUF2815 family protein	-
DQL77_RS08065	1627813..1628979	-	1167	WP_000762529.1	DUF2800 domain-containing protein	-
DQL77_RS08070	1628976..1629338	-	363	WP_000985973.1	hypothetical protein	-
DQL77_RS08075	1629353..1629676	-	324	WP_000174999.1	hypothetical protein	-
DQL77_RS08080	1629755..1629916	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
DQL77_RS08085	1629929..1630192	-	264	WP_001124193.1	helix-turn-helix domain-containing protein	-
DQL77_RS08090	1630219..1630434	-	216	WP_001097552.1	hypothetical protein	-
DQL77_RS08095	1630489..1630854	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DQL77_RS08100	1630823..1631068	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DQL77_RS08105	1631135..1631515	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
DQL77_RS08110	1631502..1631699	-	198	WP_001148860.1	hypothetical protein	-
DQL77_RS08115	1631769..1631981	+	213	WP_000362644.1	hypothetical protein	-
DQL77_RS15045	1632022..1632171	-	150	WP_000771849.1	hypothetical protein	-
DQL77_RS08120	1632186..1632629	-	444	WP_000435362.1	hypothetical protein	-
DQL77_RS08125	1632647..1632871	-	225	WP_000333485.1	DUF739 family protein	-
DQL77_RS08130	1633033..1633413	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
DQL77_RS08135	1633435..1633893	+	459	WP_000521395.1	hypothetical protein	-
DQL77_RS08140	1633911..1634345	+	435	WP_000755719.1	hypothetical protein	-
DQL77_RS08145	1634374..1634769	+	396	WP_000449656.1	hypothetical protein	-
DQL77_RS08150	1634968..1635591	-	624	WP_001166482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1590914..1654554	63640
	-	inside	Prophage	-	gnd	1590914..1662212	71298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T292626 WP_001025401.1 NZ_LS483484:c1631068-1630823 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT292626 NZ_LS483484:1630489-1630854 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin