Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1613711..1614350 Replicon chromosome
Accession NZ_LS483480
Organism Haemophilus influenzae strain NCTC13377

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag DQL19_RS08290 Protein ID WP_005650215.1
Coordinates 1614045..1614350 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQL19_RS08285 Protein ID WP_005650217.1
Coordinates 1613711..1614034 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL19_RS09630 1609456..1609629 - 174 WP_005652999.1 DUF5363 domain-containing protein -
DQL19_RS08270 1609626..1611470 - 1845 WP_015702146.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQL19_RS08275 1611475..1611816 - 342 WP_005666735.1 SirB2 family protein -
DQL19_RS08280 1611878..1613548 - 1671 WP_015702145.1 energy-dependent translational throttle protein EttA -
DQL19_RS08285 1613711..1614034 - 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
DQL19_RS08290 1614045..1614350 - 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL19_RS08295 1614675..1615295 + 621 WP_005650213.1 zinc transporter binding subunit ZevA -
DQL19_RS08300 1615298..1616266 + 969 WP_015702144.1 zinc transporter permease subunit ZevB -
DQL19_RS08310 1616881..1618920 + 2040 WP_005646675.1 excinuclease ABC subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T292620 WP_005650215.1 NZ_LS483480:c1614350-1614045 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT292620 WP_005650217.1 NZ_LS483480:c1614034-1613711 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References