292608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 760768..761416 Replicon chromosome
Accession NZ_LS483471
Organism Streptococcus cristatus strain NCTC13807

Toxin (Protein)


Gene name higB Uniprot ID A0A512AB01
Locus tag DQN71_RS03890 Protein ID WP_015604673.1
Coordinates 760768..761133 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A512AAX1
Locus tag DQN71_RS03895 Protein ID WP_015604674.1
Coordinates 761123..761416 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN71_RS03860 756482..757306 + 825 WP_015604667.1 ATP-binding protein -
DQN71_RS03865 757612..758058 + 447 WP_015604668.1 hypothetical protein -
DQN71_RS11630 758374..758550 + 177 WP_015604669.1 hypothetical protein -
DQN71_RS03870 758629..759261 + 633 WP_015604670.1 hypothetical protein -
DQN71_RS03875 759270..759752 + 483 WP_015604671.1 hypothetical protein -
DQN71_RS03880 759733..760143 + 411 WP_015604672.1 hypothetical protein -
DQN71_RS03890 760768..761133 + 366 WP_015604673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN71_RS03895 761123..761416 + 294 WP_015604674.1 helix-turn-helix transcriptional regulator Antitoxin
DQN71_RS03900 761684..762259 + 576 WP_015604675.1 hypothetical protein -
DQN71_RS03910 762477..762662 - 186 WP_015604676.1 hypothetical protein -
DQN71_RS03915 762736..763746 - 1011 WP_015604677.1 lactonase family protein -
DQN71_RS03925 763986..764252 + 267 WP_015604678.1 hypothetical protein -
DQN71_RS03930 764281..765546 + 1266 WP_015604679.1 efflux RND transporter periplasmic adaptor subunit -
DQN71_RS03935 765533..766207 + 675 WP_015604680.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 751941..766207 14266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14448.59 Da        Isoelectric Point: 9.5773

>T292608 WP_015604673.1 NZ_LS483471:760768-761133 [Streptococcus cristatus]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRVLFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELEDLKERGLDNEK

Download         Length: 366 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10678.33 Da        Isoelectric Point: 5.1991

>AT292608 WP_015604674.1 NZ_LS483471:761123-761416 [Streptococcus cristatus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A512AB01

Antitoxin

Source ID Structure
AlphaFold DB A0A512AAX1

References