Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1392979..1393639 Replicon chromosome
Accession NZ_LS483470
Organism Leminorella richardii strain NCTC12151

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DQM29_RS06565 Protein ID WP_111739947.1
Coordinates 1392979..1393332 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQM29_RS06570 Protein ID WP_111739948.1
Coordinates 1393337..1393639 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM29_RS06545 1388703..1390148 - 1446 WP_111739943.1 PLP-dependent aminotransferase family protein -
DQM29_RS06550 1390250..1390681 + 432 WP_111739944.1 carboxymuconolactone decarboxylase family protein -
DQM29_RS06555 1390776..1391447 + 672 WP_111739945.1 MmcQ/YjbR family DNA-binding protein -
DQM29_RS06560 1391533..1392696 + 1164 WP_111739946.1 winged helix-turn-helix domain-containing protein -
DQM29_RS06565 1392979..1393332 + 354 WP_111739947.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM29_RS06570 1393337..1393639 + 303 WP_111739948.1 XRE family transcriptional regulator Antitoxin
DQM29_RS06575 1394109..1394366 + 258 WP_111739949.1 antitoxin -
DQM29_RS06580 1394367..1394699 + 333 WP_111739950.1 type II toxin-antitoxin system PemK/MazF family toxin -
DQM29_RS06585 1395208..1396419 + 1212 WP_111739951.1 hypothetical protein -
DQM29_RS06590 1396436..1398118 + 1683 WP_111739952.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13482.33 Da        Isoelectric Point: 7.9654

>T292603 WP_111739947.1 NZ_LS483470:1392979-1393332 [Leminorella richardii]
VWTIKTTDRFDNWFTSLSDTDRVSVLAALMILRERGPGLPRPYADTLRGSSYSNMKELRIQSRGDPIRAFFAFDLERTGI
VLCAGNKVGNEKSFYNEMLPIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10980.74 Da        Isoelectric Point: 5.7316

>AT292603 WP_111739948.1 NZ_LS483470:1393337-1393639 [Leminorella richardii]
MGRTLEQLIADEKPEVVAEAQAVATDILLNIHLAELREKVQKTQVEMAQTLGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References