Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1675773..1676285 Replicon chromosome
Accession NZ_LS483450
Organism Streptococcus pneumoniae strain 4041STDY6583227

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag DQL12_RS08935 Protein ID WP_000924721.1
Coordinates 1675773..1676027 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag DQL12_RS08940 Protein ID WP_000388572.1
Coordinates 1676031..1676285 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL12_RS08920 1672874..1673188 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
DQL12_RS08925 1673213..1673839 - 627 WP_000775037.1 guanylate kinase -
DQL12_RS08930 1673969..1675582 - 1614 WP_000404940.1 ribonuclease Y -
DQL12_RS08935 1675773..1676027 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
DQL12_RS08940 1676031..1676285 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL12_RS08945 1676523..1677620 - 1098 WP_000156323.1 nucleotidyltransferase -
DQL12_RS08950 1677644..1679455 - 1812 WP_050217612.1 NACHT domain-containing protein -
DQL12_RS08955 1679496..1680236 - 741 WP_000257069.1 class I SAM-dependent methyltransferase -
DQL12_RS08960 1680556..1680909 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T292587 WP_000924721.1 NZ_LS483450:c1676027-1675773 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT292587 WP_000388572.1 NZ_LS483450:c1676285-1676031 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References