Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1623001..1623513 Replicon chromosome
Accession NZ_LS483448
Organism Streptococcus pneumoniae strain 4041STDY6836167

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag DQK99_RS08755 Protein ID WP_000924721.1
Coordinates 1623001..1623255 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag DQK99_RS08760 Protein ID WP_000388572.1
Coordinates 1623259..1623513 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQK99_RS08740 1620102..1620416 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
DQK99_RS08745 1620441..1621067 - 627 WP_000775037.1 guanylate kinase -
DQK99_RS08750 1621197..1622810 - 1614 WP_000404929.1 ribonuclease Y -
DQK99_RS08755 1623001..1623255 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
DQK99_RS08760 1623259..1623513 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQK99_RS08765 1623751..1624848 - 1098 WP_000156323.1 nucleotidyltransferase -
DQK99_RS08770 1624858..1625598 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
DQK99_RS08775 1625918..1626271 - 354 WP_001003001.1 ribosome silencing factor -
DQK99_RS08780 1626284..1626784 - 501 WP_000844717.1 cysteine hydrolase -
DQK99_RS08785 1626785..1627378 - 594 WP_000121648.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
DQK99_RS08790 1627378..1628007 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
DQK99_RS08795 1628059..1628370 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T292578 WP_000924721.1 NZ_LS483448:c1623255-1623001 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT292578 WP_000388572.1 NZ_LS483448:c1623513-1623259 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References