Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1645704..1646216 Replicon chromosome
Accession NZ_LS483444
Organism Streptococcus australis strain NCTC13166

Toxin (Protein)


Gene name yoeB Uniprot ID E7S9T4
Locus tag DQL20_RS08595 Protein ID WP_006595728.1
Coordinates 1645704..1645958 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DQL20_RS08600 Protein ID WP_006597166.1
Coordinates 1645962..1646216 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL20_RS08575 1641611..1642492 - 882 WP_006595732.1 MetQ/NlpA family ABC transporter substrate-binding protein -
DQL20_RS08580 1642526..1643353 - 828 WP_006595731.1 amino acid ABC transporter substrate-binding protein -
DQL20_RS08585 1643482..1644624 - 1143 WP_006597168.1 amidohydrolase -
DQL20_RS08590 1644813..1645529 - 717 WP_006595729.1 YebC/PmpR family DNA-binding transcriptional regulator -
DQL20_RS08595 1645704..1645958 - 255 WP_006595728.1 Txe/YoeB family addiction module toxin Toxin
DQL20_RS08600 1645962..1646216 - 255 WP_006597166.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQL20_RS08605 1646450..1647544 - 1095 WP_006595726.1 nucleotidyltransferase -
DQL20_RS08610 1647551..1648291 - 741 WP_006595725.1 class I SAM-dependent methyltransferase -
DQL20_RS08620 1648883..1649236 - 354 WP_006595724.1 ribosome silencing factor -
DQL20_RS08625 1649251..1649751 - 501 WP_006595723.1 cysteine hydrolase -
DQL20_RS08630 1649752..1650348 - 597 WP_006595722.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
DQL20_RS08635 1650348..1650977 - 630 WP_006595721.1 nicotinate-nucleotide adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10068.52 Da        Isoelectric Point: 7.9789

>T292574 WP_006595728.1 NZ_LS483444:c1645958-1645704 [Streptococcus australis]
MLLKFTEDAWKDYCYWQSQDKKTLKRINSLIKEIQRDPFAGIGKPEPLKYDFQGAWSRRIDAENRLIYMLDESGVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9669.96 Da        Isoelectric Point: 4.6768

>AT292574 WP_006597166.1 NZ_LS483444:c1646216-1645962 [Streptococcus australis]
MEAVVYSTFRNHLKDYMKKVNDELEPLTVVNKNPDEDIVVISKSEWDSLQETLRLAQNKELSDKVLRGMAEVRAGQVQLH
EIEG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z1DV35

Antitoxin

Source ID Structure

References