Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1222897..1223536 Replicon chromosome
Accession NZ_LS483438
Organism Haemophilus influenzae strain NCTC12975

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag DQN45_RS06010 Protein ID WP_005650215.1
Coordinates 1222897..1223202 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DQN45_RS06015 Protein ID WP_005650217.1
Coordinates 1223213..1223536 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN45_RS05990 1218327..1220366 - 2040 WP_038441065.1 excinuclease ABC subunit B -
DQN45_RS06000 1220981..1221949 - 969 WP_042593950.1 zinc transporter permease subunit ZevB -
DQN45_RS06005 1221952..1222572 - 621 WP_005694310.1 zinc transporter binding subunit ZevA -
DQN45_RS06010 1222897..1223202 + 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN45_RS06015 1223213..1223536 + 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
DQN45_RS06020 1223699..1225369 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
DQN45_RS06025 1225431..1225772 + 342 WP_005652996.1 SirB2 family protein -
DQN45_RS06030 1225777..1227747 + 1971 WP_011961904.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQN45_RS09215 1227744..1227917 + 174 WP_011272700.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T292570 WP_005650215.1 NZ_LS483438:1222897-1223202 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT292570 WP_005650217.1 NZ_LS483438:1223213-1223536 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References