Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 379113..380461 Replicon chromosome
Accession NZ_LS483438
Organism Haemophilus influenzae strain NCTC12975

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag DQN45_RS01885 Protein ID WP_042593553.1
Coordinates 379430..380461 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S9R6P7
Locus tag DQN45_RS01880 Protein ID WP_005650823.1
Coordinates 379113..379433 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN45_RS01840 374540..374818 + 279 WP_042593548.1 cell division protein FtsB -
DQN45_RS01845 374818..375495 + 678 WP_042593549.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DQN45_RS01850 375492..375968 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
DQN45_RS01855 376273..376707 - 435 WP_013526377.1 D-tyrosyl-tRNA(Tyr) deacylase -
DQN45_RS01860 376704..377144 - 441 WP_005694621.1 FMN-binding protein MioC -
DQN45_RS01865 377241..377459 - 219 WP_005650820.1 cell division protein ZapB -
DQN45_RS01870 377621..378622 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
DQN45_RS01875 378817..379125 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
DQN45_RS01880 379113..379433 + 321 WP_005650823.1 type II toxin-antitoxin system HipA family toxin Antitoxin
DQN45_RS01885 379430..380461 + 1032 WP_042593553.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN45_RS01890 380545..382203 - 1659 WP_042593554.1 thiol reductant ABC exporter subunit CydC -
DQN45_RS01895 382196..383941 - 1746 WP_042593556.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39870.45 Da        Isoelectric Point: 6.6398

>T292567 WP_042593553.1 NZ_LS483438:379430-380461 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLHEPEL

Download         Length: 1032 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12404.04 Da        Isoelectric Point: 5.8850

>AT292567 WP_005650823.1 NZ_LS483438:379113-379433 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9R6P7

References